Report on carcinogens

Dec 21, 2021 · In nursing mice, a single intraperitoneal injection of β-propiolactone caused lymphoma in both sexes and liver tumors (hepatocellular tumors) in males. Since β-propiolactone was listed in the Second Annual Report on Carcinogens, additional studies in experimental animals have been identified. In female mice, oral exposure to β-propiolactone ...

Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see theGlossary. chemical composition of a field sample seldom matches the idealized formula. Amphibole fibers do not divide into fibrils as small in di-ameter or as symmetrical as chrysotile fibers, and they do not have a hollow central core. 6 Nov 2016 ... The National Institutes of Health (NIH) released its 14th Report on Carcinogens last week (November 3), bringing the total number of ...Abstract. This study evaluates the National Toxicology Program’s Report on Carcinogens program (RoCP) and compares it with the International Agency for Research on Cancer Monographs Program (IMP). We tracked agents classified in the RoCP since 1983 as known human carcinogens (A-List), or as reasonably anticipated to be human carcinogens (B-List).Mandated in 1978 by an act of the U.S. Congress, the Report on Carcinogens lists agents as either “known to be a human carcinogen” or “reasonably anticipated to be a human carcinogen.” One nongovernmental and two federal scientific committees review the nominations for listing in or delisting from the Report on Carcinogens.Apr 6, 2023 · Specifically, the NTP publishes the Report on Carcinogens every few years. This congressionally mandated publication identifies agents, substances, mixtures, or exposures (collectively called “substances”) in the environment that may cause cancer in humans. The 2021 edition lists 63 known human carcinogens and includes descriptions of the ...

Since 1,4-dioxane was listed in the Second Annual Report on Carcinogens, additional studies in rodents have been identified. 1,4-Dioxane administered in the drinking water increased the com-bined incidence of benign and malignant liver tumors (hepatocellu-lar adenoma and carcinoma) in rats and mice of both sexes.Aflatoxins are known to be human carcinogens based on sufficient evidence of carcinogenicity from studies in humans. Aflatoxins were listed in the First Annual Report on Carcinogens as reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals and limited evidence of carcinogenicity from studies in humans; however, the ...The Report on Carcinogens (RoC) is an informational scientific and public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances that may pose a hazard to human health by virtue of their carcinogenicity.11th Report on Carcinogens 11th Report on Carcinogens U.S. Department of Health and Human Services Public Health Service National Toxicology Program Pursuant to Section 301(b) (4) of the Public Health Service Act as Amended by Section 262, PL 95-622 Official Citation: Report on Carcinogens, Eleventh Edition; U.S. Department of Health andIn nursing mice, a single intraperitoneal injection of β-propiolactone caused lymphoma in both sexes and liver tumors (hepatocellular tumors) in males. Since β-propiolactone was listed in the Second Annual Report on Carcinogens, additional studies in experimental animals have been identified. In female mice, oral exposure to β …

listed in the First Annual Report on Carcinogens as reasonably antic-ipated to be human carcinogens based on sufficient evidence of carci-nogenicity from studies in experimental animals and limited evidence of carcinogenicity from studies in humans; however, the listing was revised to known to be human carcinogens in the Sixth Annual Re-22 Apr 2018 ... ... carcinogens #pesticides #contaminants # ... carcinogens (cancer causing agents) in our environment. ... Report. Comments. thumbnail-image. Add a ...Since PCBs were listed in the Second Annual Report on Carcinogens, additional studies of dietary exposure in rats have been identified, which found that (1) additional PCB mixtures or individual congeners caused tumors, (2) specific PCB mixtures or congeners caused liver tumors in male rats, and (3) PCB mixtures or congeners caused tumors at ...Reports are also expected from petroleum refineries. The final rule is effective for the 2011 reporting year with the first reports due July 1, 2012. EPA added 16 chemicals to the TRI list of reportable chemicals. Each chemical has been classified as "reasonably anticipated to be a human carcinogen" by the National Toxicology Program.

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Dec 21, 2021 · Tobacco contains more than 2,500 chemical constituents, many of which are known human carcinogens. Tobacco smoking produces both mainstream smoke, which is drawn through the tobacco column and exits through the mouthpiece during puffing, and sidestream smoke, which is emitted from the smoldering tobacco between puffs. Chewing tobacco and snuff are the two main forms of smokeless tobacco used ... ArticlePDF Available. Final Report on Carcinogens Background Document for Formaldehyde. January 2010. Authors: Luoping Zhang. University of California, Berkeley. Ruth Mae Lunn.The Report on Carcinogens staff is responsible for carrying out this activity within DTT/NIEHS and prepares a monograph for each substance evaluated for listing in the RoC (i.e., a candidate substance). The monograph is a literature-based review document that captures the cancer hazard evaluation.Over 460 million metric tons of plastic are produced every year for use in a wide variety of applications. An estimated 20 million metric tons of plastic litter end up in the environment every year. That amount is expected to increase significantly by 2040. Plastic pollution affects all land, freshwater, and marine ecosystems. It is a major driver of biodiversity …Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see theGlossary. Production Naphthalene is produced from either coal tar (which contains ap-proximately 10% naphthalene), by condensation and separation of coal tar from coke-oven gases, or from petroleum, by dealkylation of methylnaphthalenes.

Finally, NTP applied the Report on Carcinogens (RoC) listing criteria to its assessment to reach an overall cancer hazard conclusion. Results and Discussion: Epidemiological studies demonstrated ...On November 2, KT releases figures for Q3.Analysts expect KT will report earnings per share of KRW 902.77.Go here to track KT stock price in real-... KT will be reporting Q3 earnin...The Report on Carcinogens (RoC) is prepared in response to Section 301 of the Public Health Service Act as amended. The RoC contains a list of identified substances (i) that either are known to be human carcinogens or are reasonably be anticipated to be human carcinogens and (ii) to which a significant number of persons residing in the UnitedReport on Carcinogens . The Report on Carcinogens (RoC) is a Congressionally mandated, science-based public health document that identifies and discusses . agents, substances, mixtures, or exposure circumstances (collectively referred to as “substances”) that pose a cancer hazard for persons in the United States. Substances are listed in ...Studies on Mechanisms of Carcinogenesis. Chloramphenicol inhibits protein synthesis in the mitochondria of mammalian cells (by binding to ribosomes), which accounts for the sensitivity of proliferating tissues, such as those that promote the formation of blood cells, to its toxicity. Anemia, including aplastic anemia, is a recognized hazard ... The RoC monograph on H. pylori provides a concise review of the evidence from cancer studies in humans and experimental animals, as well as information on human exposure to H. pylori. As H. pylori is thought to account for 6.2% of all cancer deaths in the world, primarily due to non-cardia gastric cancer, the monograph also provides a summary ... The Report on Carcinogens review groups considered the data underlying the nomination to remove ethyl acrylate from the Report on Carcinogens, where it has been listed as reasonably anticipated to be a human carcinogen since 1989. The basis for this listing was a gavage study that resulted in dose-related benign and malignant …Indices Commodities Currencies StocksHeterocyclic amines (HCAs) are formed during the cooking of meat, by condensation of creatinine with amino acids. Four individual HCAs are listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen (in separate listings): 2-Amino-3,4-dimethylimidazo [4,5- f ]quinoline (MeIQ) was first listed in the Eleventh …First listed in the Twelfth Report on Carcinogens (2011) Carcinogenicity. Aristolochic acids are known to be human carcinogens based on sufficient evidence of carcinogenicity from studies in humans and supporting data on mechanisms of carcinogenesis. Evidence of carcinogenicity from studies in experimental animals … The RoC monograph on H. pylori provides a concise review of the evidence from cancer studies in humans and experimental animals, as well as information on human exposure to H. pylori. As H. pylori is thought to account for 6.2% of all cancer deaths in the world, primarily due to non-cardia gastric cancer, the monograph also provides a summary ... Opisthorchis viverrini (infection with), also known as the Southeast Asian liver fluke. Opium consumption. Outdoor air pollution (and the particulate matter in it) Painter (workplace exposure as a) 3,4,5,3',4'-Pentachlorobiphenyl (PCB-126) 2,3,4,7,8-Pentachlorodibenzofuran. Pentachlorophenol.

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A: On August 12, 2014, a panel of experts reviewed the Draft Report on Carcinogens Monograph on Antimony Trioxide and unanimously agreed with NTP’s recommended listing, reasonably anticipated to be a human carcinogen. The panel included experts in public health, toxicology, pathology, and other fields.Administration of chloroform by stom-ach tube caused liver cancer (hepatocellular carcinoma) in mice of both sexes (NCI 1976) and kidney tumors (epithelial tumors) in male mice and rats (IARC 1979, Roe et al. 1979). Since chloroform was listed in the Second Annual Report on Car-cinogens, additional studies in rodents have been identified, which ...According to About.com, petroleum jelly, which is found in Vaseline, contains polycyclic aromatic hydrocarbons from unrefined petrolatum that are considered to be carcinogenic. Whi...Verdict: TRUE. The colour of plastic does not inherently determine its chemical content; it is the composition and manufacturing process that dictate whether harmful substances are present. The ...The analysis demonstrates how the Report on Carcinogens, which identifies cancer-causing substances, has impacted public health policies. By Robin Mackar How can anyone tell if the research they are conducting is making a difference? That is a question staff in the Division of Translational Toxicology wanted to answer.Apr 6, 2023 · Specifically, the NTP publishes the Report on Carcinogens every few years. This congressionally mandated publication identifies agents, substances, mixtures, or exposures (collectively called “substances”) in the environment that may cause cancer in humans. The 2021 edition lists 63 known human carcinogens and includes descriptions of the ... Appendix A. Cancer Hazards Not Included in the NTP Report on Carcinogens; Appendix B. Substances Delisted from the Report on Carcinogens; Appendix C. Substances Reviewed but Not Recommended for Listing in the Report on Carcinogens; Appendix D. 15th RoC and Monographs - Collaborators and Contributors

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中文. Français. Русский. Español. Key facts. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. The most common cancers are breast, lung, …Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see theGlossary. chemical composition of a field sample seldom matches the idealized formula. Amphibole fibers do not divide into fibrils as small in di-ameter or as symmetrical as chrysotile fibers, and they do not have a hollow central core.A Mississauga factory is using a known carcinogen. Residents had no idea. High levels of ethylene oxide were detected near a now-closed Scarborough plant owned by Sterigenics, which has agreed to pay over US$400 million to claimants alleging cancer in the U.S. The company has since moved to Mississauga. By Leah Borts-Kuperman and … The 15th Report on Carcinogens contains information on 256 substances — 63 known to be human carcinogens and 193 reasonably anticipated to be human carcinogens — including some classes of related chemicals or substances. The Report on Carcinogens is a cumulative report. It includes information on the newly reviewed substances, as well as ... A chronic bacterial infection, a flame retardant, and six water disinfection byproducts are listed in a new HHS cancer report. Eight substances have been added to the Report on Carcinogens, bringing the total list to 256 substances that are known, or reasonably anticipated, to cause cancer in humans. This is the 15th Report on Carcinogens ... Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see theGlossary. significantly higher risks (or elevated risks approaching statistical significance) than did workers in the lowest exposure group for all lymphohematopoietic cancer (relative risk [RR] = 3.08, 95% confi- Administration of chloroform by stom-ach tube caused liver cancer (hepatocellular carcinoma) in mice of both sexes (NCI 1976) and kidney tumors (epithelial tumors) in male mice and rats (IARC 1979, Roe et al. 1979). Since chloroform was listed in the Second Annual Report on Car-cinogens, additional studies in rodents have been identified, which ...Have you ever found yourself stuck in traffic, wishing you had known about the congestion ahead of time? With the advancement of technology, accessing real-time traffic reports has...If you’re in the market for a used car, one of the most important pieces of information you’ll need is its history report. A vehicle history report provides detailed information ab...Tobacco contains more than 2,500 chemical constituents, many of which are known human carcinogens. Tobacco smoking produces both mainstream smoke, which is drawn through the tobacco column and exits through the mouthpiece during puffing, and sidestream smoke, which is emitted from the smoldering tobacco between puffs. Chewing tobacco and snuff are the two main forms of smokeless tobacco used ...Nitrobenzene is structurally related to other aromatic nitro and amino compounds, including several nitroarenes listed in the Report on Carcinogens as reasonably anticipated to be human carcinogens and classified by the International Agency for Research on Cancer as possibly carcinogenic to humans . ….

in the Ninth Report on Carcinogens (2000). The profiles for each of these substances and exposure circumstances, which are listed (sep - arately) as known to be a human carcinogen, follow this introduction. Tobacco Smoking CAS No.: none assigned Known to be a human carcinogen First listed in the Ninth Report on Carcinogens …Reports are also expected from petroleum refineries. The final rule is effective for the 2011 reporting year with the first reports due July 1, 2012. EPA added 16 chemicals to the TRI list of reportable chemicals. Each chemical has been classified as "reasonably anticipated to be a human carcinogen" by the National Toxicology Program.Trichloroethylene was first listed in the Ninth Report on Carcinogens in 2000 as reasonably anticipated to be a human carcinogen based on limited evidence of carcinogenicity from studies in humans, sufficient evidence of carcinogenicity from studies in experimental animals, and information from studies on mechanisms of carcinogenesis. ...The Report on Carcinogens (RoC) is prepared in response to Section 301 of the Public Health Service Act as amended. The RoC contains a list of identified substances (i) that either are known to be human carcinogens or are reasonably be anticipated to be human carcinogens and (ii) to which a significant number of persons residing in the UnitedCancer Studies in Humans. Tobacco smoking has been shown to cause cancer of the lung, urinary bladder, renal pelvis, oral cavity, pharynx, larynx, esophagus, lip, and pancreas in humans ( IARC 1986 ). The risk of death from lung cancer increases with increasing duration of smoking and with increasing numbers of cigarettes smoked.The Report on Carcinogens is an informational scientific and public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances that may pose a carcinogenic hazard to human health. It serves as a meaningful and useful compilation of data on the (1) carcinogenicity, genotoxicity, and …N-Nitrosamines are a class of chemical compounds with the general structure shown in the figure. The essential feature of N-nitroso compounds is the N–N=O structure; the R1 and R2 groups attached to the amine nitrogen may range from a simple hydrogen (H) atom to more complex chemical substituents (including ring structures that incorporate the nitrogen atom), as shown in the structures of ...Cancer Studies in Experimental Animals. Studies in experimental animals, including many published after benzene was listed in the First Annual Report on Carcinogens, have demonstrated that benzene causes cancer at numerous tissue sites in rodents. Oral exposure to benzene caused cancer of the Zymbal gland (carcinoma) in …Dec 21, 2021 · Tobacco contains more than 2,500 chemical constituents, many of which are known human carcinogens. Tobacco smoking produces both mainstream smoke, which is drawn through the tobacco column and exits through the mouthpiece during puffing, and sidestream smoke, which is emitted from the smoldering tobacco between puffs. Chewing tobacco and snuff are the two main forms of smokeless tobacco used ... Report on carcinogens, Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens concurs with the NTP determination that there is limited but credible evidence that exposure to styrene in some occupational settings is associated with an increase in the frequency of lymphohematopoietic cancers. Additionally, the NRC report ..., Radon is a naturally occurring, odorless, and colorless gas that can be found in homes and buildings. It is a known carcinogen and can be hazardous to your health if it accumulates..., 1-Bromopropane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. 1-Bromopropane, either directly or via reactive metabolites, causes molecular alterations that typically are associated with carcinogenesis, including genotoxicity, oxidative stress, and …, Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see theGlossary. Production Naphthalene is produced from either coal tar (which contains ap-proximately 10% naphthalene), by condensation and separation of coal tar from coke-oven gases, or from petroleum, by dealkylation of methylnaphthalenes., Since epichlorohydrin was listed in the Fourth Annual Report on Carcinogens, the International Agency for Research on Cancer has reviewed its carcinogenicity twice ( IARC 1987, IARC 1999 ). The 1999 review included a follow-up study of the cohort exposed to epichlorohydrin and isopropyl alcohol (Enterline 1982), as well as additional cohort and ..., August 8, 2014. A new report from the National Research Council has upheld the listing of formaldehyde as “known to be a human carcinogen” in the National Toxicology Program 12th Report on Carcinogens (RoC). The committee that wrote the Research Council report found that the listing is supported by sufficient evidence from human studies ..., Properties. Elemental chromium is a transition-group metal belonging to group VIB of the periodic table and has oxidation states ranging from −2 to +6, of which the divalent (+2, II), trivalent (+3, III), and hexavalent (+6, VI) forms are the most important. Elemental chromium does not occur naturally in the environment., Report on Carcinogens: Identifying Carcinogens. The Report on Carcinogens (RoC) is a congressionally mandated, science-based, public health report that provides a cumulative list of known or reasonably anticipated human carcinogens., Apr 6, 2023 · Specifically, the NTP publishes the Report on Carcinogens every few years. This congressionally mandated publication identifies agents, substances, mixtures, or exposures (collectively called “substances”) in the environment that may cause cancer in humans. The 2021 edition lists 63 known human carcinogens and includes descriptions of the ... , Dec 21, 2021 · Formaldehyde is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans and supporting data on mechanisms of carcinogenesis. Formaldehyde was first listed in the Second Annual Report on Carcinogens in 1981 as reasonably anticipated to be a human carcinogen based on sufficient evidence from studies in experimental animals. Since that time ... , Sixth Annual Report on Carcinogens, one epidemiological study of BHA has been identi-fied. A population-based nested case-control study of stomach cancer in men and women within the Netherlands Cohort Study of dietary intake found no increase in risk at typical levels of dietary intake of BHA (Botterweck. et al. 2000). Properties, the Ninth Report on Carcinogens in 2000, the International Agency for Research on Cancer has reevaluated the evidence for the carcinoge-nicity of alcoholic beverage consumption (Baan et al. 2007, Secretan et al. 2009) and concluded that there was sufficient evidence of carci-nogenicity in humans. The 2007 and 2009 reviews concluded that al-, ortho-Toluidine is a high-production-volume synthetic chemical used to manufacture rubber chemicals, herbicide intermediates, dye intermediates, and the local anesthetic prilocaine. People are exposed to high levels of ortho-toluidine via inhalation or through the skin in workplaces that use it. ortho-Toluidine is found in urine and blood of individuals without known occupational exposure to ..., The data available from epidemiological studies are inadequate to evaluate the relationship between human cancer and exposure specifically to toxaphene. Since toxaphene was listed in the Second Annual Report on Carcinogens, additional epidemiological studies have been identified. Two case-control studies, one for non …, Dec 23, 2021 · Eight substances have been added to the Report on Carcinogens, bringing the total list to 256 substances that are known, or reasonably anticipated, to cause cancer in humans. This is the 15th Report on Carcinogens , which is a cumulative report, mandated by Congress and prepared by the National Toxicology Program (NTP) for the Secretary of the ... , 1-Bromopropane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. 1-Bromopropane, either directly or via reactive metabolites, causes molecular alterations that typically are associated with carcinogenesis, including genotoxicity, oxidative stress, and …, The Report on Carcinogens (RoC) is an informational scientific and public health document that identifies and discusses agents, substances, mixtures, or exposure circumstances that may pose a hazard to human health by virtue of their carcinogenicity., The 15th Report on Carcinogens contains information on 256 substances — 63 known to be human carcinogens and 193 reasonably anticipated to be human carcinogens — including some classes of related chemicals or substances. The Report on Carcinogens is a cumulative report. It includes information on the newly reviewed substances, as well as ..., Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see theGlossary. The U.S. Food and Drug Administration has regulated the use of acrylamide and polyacrylamide in foods (IARC 1994). Acrylamide polymers containing less than 0.2% monomer may be used in food-packaging adhesives, paper, and paperboard; to wash or …, Since asbestos was listed in the First Annual Report on Carcinogens, the evidence for the carcinogenicity of asbestos has been reevaluated by the Institute of Medicine (IOM) of the National Academy of Sciences in 2006 and by IARC in 2009 (Straif et al. 2009). IARC concluded that exposure to all forms of asbestos (chrysotile, crocidolite ..., Ethyl methanesulfonate is the ethyl ester of methanesulfonic acid and exists as a colorless liquid at room temperature ( IARC 1974 ). It is soluble in water and stable under normal temperatures and pressures ( Akron 2009 ). Physical and chemical properties of ethyl methanesulfonate are listed in Table 1. Table 1., Known to be a human carcinogen First listed in the Ninth Report on Carcinogens (2000) Also known as 1,1,2-trichloroethene or TCE H C C Cl Cl Cl Carcinogenicity Trichloroethylene is known to be a human carcinogen based on suffi-cient evidence of carcinogenicity from studies in humans. This con-, Mandated in 1978 by an act of the U.S. Congress, the Report on Carcinogens lists agents as either “known to be a human carcinogen” or “reasonably anticipated to be a human carcinogen.” One nongovernmental and two federal scientific committees review the nominations for listing in or delisting from the Report on Carcinogens., Dec 21, 2021 · The agents, substances, mixtures, or exposure circumstances contained in this appendix were previously listed in the Report on Carcinogens (RoC) as either known or reasonably anticipated to be human carcinogens. For substances removed from the RoC prior to the 1996 establishment of a formal review procedure for delisting substances from the RoC, Table B-1 below shows the reason for delisting ... , Wood dust usually is measured as the concentration of airborne dust, by particle size distribution, by type of wood, and by other characteristics of wood. Total airborne dust concentration is reported as mass per unit volume (usually milligrams of dust per cubic meter of air). Wood dust generally is collected by a standard gravimetric …, The National Toxicology Program (NTP) conducted a cancer hazard evaluation of EBV infection and seven types of cancer for possible listing in the Report on Carcinogens (RoC). The evaluation included the findings from studies reported in the IARC monograph in Volume 100B, as well as from human cancer studies and mechanistic studies and reviews ..., The report identifies agents, substances, mixtures, or exposures in two categories: known to be a human carcinogen and reasonably anticipated to be a human carcinogen. A listing in the Report on Carcinogens does not by itself mean that a substance will cause cancer. , The Report on Carcinogens is a congressionally mandated, science-based public health document that NTP prepares for the HHS Secretary. This cumulative report now includes 256 listings of substances — chemical, physical, and biological agents; mixtures; and exposure circumstances — that are known or reasonably anticipated to cause cancer in ..., The Report on Carcinogens (RoC) is a scientific and public health document mandated by Congress in 1978. The RoC identifies and discusses substances, chemicals, mixtures, or exposure circumstances (collectively called substances) that may pose a cancer hazard to human health and to which persons in the United States are exposed. Nominations to ..., The NTP cancer hazard evaluation was the basis for changing the listing status of TCE from reasonably anticipated to known to be a human carcinogen in the 14th edition of the Report on Carcinogens based on sufficient evidence …, Over 460 million metric tons of plastic are produced every year for use in a wide variety of applications. An estimated 20 million metric tons of plastic litter end up in the environment every year. That amount is expected to increase significantly by 2040. Plastic pollution affects all land, freshwater, and marine ecosystems. It is a major driver of biodiversity …, The Report on Carcinogens (RoC) is prepared in response to Section 301 of the Public Health Service Act as amended. The RoC contains a list of identified substances (i) that either are known to be human carcinogens or are reasonably be anticipated to be human carcinogens and (ii) to which a significant number of persons residing in the United, Since technical grade 1,3-dichloropropene was listed in the Fifth Annual Report on Carcinogens, an ecological case-control study of pancreatic cancer mortality (from 1989 to 1996) and exposure to organochlorine pesticides was reported. The authors reported an increase in pancreatic cancer mortality among long-term residents in areas with high ...